KOTRESHA NEELAKANTAPPA, M.D.; GLORIA R. GALLO, M.D.; DAVID S. BALDWIN, M.D.
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To the editor: Immunoglobulin A nephropathy occurs with an unusually low incidence in blacks (1). There has been no apparent explanation for this so far. Immunoglobulin A1 is the predominant subtype in human serum, and most evidence shows that IgA1 is the immunoglobulin involved in the glomerulus and in immune complexes in IgA nephropathy. However, IgA2 is thought to be important in the first-line defense against the offending antigen at the mucosal surface (2). The genetic marker A2m(1) identified on the Fc portion of the heavy chain of IgA2 occurs with the highest incidence (gene frequency, 0.99) in whites and
NEELAKANTAPPA K, GALLO GR, BALDWIN DS. Immunoglobulin A Nephropathy in Blacks and Homozygosity for the Genetic Marker A2m. Ann Intern Med. 1986;104:287–288. doi: https://doi.org/10.7326/0003-4819-104-2-287_2
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Published: Ann Intern Med. 1986;104(2):287-288.
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