KYLE W. STRADER, M.D.; CHRISTOPHER M. WISE, M.D.; BENEDICT L. WASILAUSKAS, M.D.; WILLIAM L. SALZER, M.D.
Plasmid-Mediated (beta-lactamase positive) and chromosomally mediated (beta-lactamase negative) forms of penicillin resistance have been reported with mucosal Neisseria gonorrhoeae isolates (1, 2). However, there have only been six reported cases of disseminated gonococcal infections with beta-lactamase-producing organisms (3-5), and no reports documenting isolation of chromosomally mediated penicillin-resistant organisms from a disseminated site. We report the isolation of N. gonorrhoeae that was beta-lactamase negative but highly resistant to penicillin from the synovial fluid of two patients.
Organisms were identified as N. gonorrhoeae on the basis of Gram stain, oxidase testing, and sugar fermentation reactions. Beta-lactam reagent disks (Marion Laboratories, Kansas City,
STRADER KW, WISE CM, WASILAUSKAS BL, SALZER WL. Disseminated Gonococcal Infection Caused by Chromosomally Mediated Penicillin-Resistant Organisms. Ann Intern Med. ;104:365–366. doi: 10.7326/0003-4819-104-3-365
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Published: Ann Intern Med. 1986;104(3):365-366.
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