DONNA B. GREENBERG, M.D.
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To the editor: To scrutinize the diagnosis of chronic Epstein-Barr virus infection in a symposium (1) without psychiatrists and without careful attention to psychiatric data is to look with only one eye. This syndrome is characterized primarily by chronic fatigue, a symptom linked intimately to depression and anxiety. Of patients with major depressive disorder, 90% have loss of energy. Many medical illnesses from myocardial infarction to breast cancer are complicated by depression. Acute mononucleosis is no different. Time until recovery from untreated depression may also be protracted.
Most patients reported with chronic Epstein-Barr virus infection have been women aged 25
GREENBERG DB. Depression, Anxiety, and Epstein-Barr Virus Infection. Ann Intern Med. 1986;104:449. doi: https://doi.org/10.7326/0003-4819-104-3-449_1
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Published: Ann Intern Med. 1986;104(3):449.
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