CHARLES P. TALIERCIO, M.D.; RONALD E. VLIETSTRA, M.B., Ch.B.; LLOYD D. FISHER, Ph.D.; JOHN C. BURNETT, M.D.
In 139 patients with preexisting abnormal renal function (serum creatinine level of 2.0 mg/dL or greater) undergoing cardiac angiography (141 examinations), the incidence of contrast nephropathy, defined as a 1 mg/dL or greater rise in serum creatinine, was 23% (95% confidence interval, 17% to 30%). Stepwise logistic regression analysis showed that contrast nephropathy was independently associated with class IV heart failure with low cardiac output (71% incidence in this subgroup; p < 0.0001), multiple radiocontrast studies within 72 hours (50%; p = 0.002), dose of radiocontrast administered (p = 0.009), and insulin-dependent diabetes mellitus (44%; p = 0.007). Age, hypertension, and hyperuricemia were not associated. In patients without low cardiac output, other radiocontrast tests, or insulin-dependent diabetes mellitus, there was a 2% incidence of contrast nephropathy in those who received less than 125 mL radiocontrast and a 19% incidence in those who received 125 mL or greater.
TALIERCIO CP, VLIETSTRA RE, FISHER LD, et al. Risks for Renal Dysfunction with Cardiac Angiography. Ann Intern Med. 1986;104:501–504. doi: 10.7326/0003-4819-104-4-501
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Published: Ann Intern Med. 1986;104(4):501-504.
Cardiac Diagnosis and Imaging, Cardiology, Nephrology.
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