JOEL E. RICHTER, M.D.
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To the editor: In the January issue, Lieberman and Keeffe (1) presented a well-designed study comparing a regimen of cimetidine alone to one of cimetidine and metoclopramide in the treatment of severe reflux esophagitis. Their study should be of particular interest to the practicing physician, because the patients had severe esophagitis that had not previously responded to treatment with an H2-receptor antagonist. This subset of patients with gastroesophageal reflux is the most difficult to treat, and unfortunately their problem has not been addressed by previous clinical studies. Several comments, however, are pertinent to the article and the accompanying editorial (2).
RICHTER JE. Treatment of Severe Reflux Esophagitis. Ann Intern Med. ;104:588–589. doi: 10.7326/0003-4819-104-4-588_3
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Published: Ann Intern Med. 1986;104(4):588-589.
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