N. PETER ZAUBER, M.D.; MICHAEL W. STARK, M.D.
Protein C deficiency is an autosomal-dominant disorder associated with recurrent thromboembolism (1). Prevention of the thromboembolic problems requires long-term anticoagulation, but the initiation of oral anti-coagulation therapy in patients with protein C deficiency may be complicated by skin necrosis (2). We present the case of a patient with protein C deficiency for whom anti-coagulation treatment with warfarin was successful, despite prior warfarin necrosis.
A 44-year-old man of Greek ancestry developed a left femoral artery thrombosis in 1981 after myelography. He was placed on treatment with warfarin without difficulty and continued the therapy for 8 months. In 1982 he developed right
ZAUBER NP, STARK MW. Successful Warfarin Anticoagulation Despite Protein C Deficiency and a History of Warfarin Necrosis. Ann Intern Med. ;104:659–660. doi: 10.7326/0003-4819-104-5-659
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Published: Ann Intern Med. 1986;104(5):659-660.
Coagulopathies, Hematology/Oncology, Venous Thromboembolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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