JOHN OSTERLOH, M.D.; KENT OLSON, M.D.
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To the editor: Methemoglobinemia following the overdose of alkyl nitrites has been reported in eight cases (references available on request) in addition to the one reported by Laaban and colleagues (1). This is in contrast to their statement that this acute toxicity has been underreported (1). We have followed another five patients who ingested alkyl nitrites (including amyl, butyl, and isobutyl nitrites).
In our 5 patients and in the 9 patients described in the literature, butyl or isobutyl nitrite was reported as the ingested agent in 10 patients and amyl nitrite in 2. Quantities ingested were reported as 10 to
OSTERLOH J, OLSON K. Toxicities Of Alkyl Nitrites. Ann Intern Med. ;104:727. doi: 10.7326/0003-4819-104-5-727_1
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Published: Ann Intern Med. 1986;104(5):727.
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