MICHAEL A. BAUMANN, M.D.; JAY E. MENITOVE, M.D.; RICHARD H. ASTER, M.D.; TOM ANDERSON, M.D.
Intravenous administrations of high-dose gammaglobulin increases the peripheral blood platelet counts of most patients with idiopathic thrombocytopenic purpura (1-8). The mechanism of this effect has been thought to be a "blockade" by exogenous immunoglobulin of Fc receptors on phagocytic macrophages, with resultant inhibition of binding and removal from circulation of immunoglobulin-coated platelets (2, 8). Unfortunately, therapy as previously reported entails administration of a dose of 1.0 to 2.0 g/kg body weight given over 4 to 5 days (1-8), at a cost of approximately $6000 for a 5-day course in a person weighing 70 kg. Because responses are usually transient (1-8),
BAUMANN MA, MENITOVE JE, ASTER RH, ANDERSON T. Urgent Treatment of Idiopathic Thrombocytopenic Purpura with Single-Dose Gammaglobulin Infusion Followed by Platelet Transfusion. Ann Intern Med. ;104:808–809. doi: 10.7326/0003-4819-104-6-808
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Published: Ann Intern Med. 1986;104(6):808-809.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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