EDUARDO BRUERA, M.D.; NEIL MACDONALD, M.D., F.R.C.P. (C); CARLEEN BRENNEIS; IAIN SIMPSON; DONALD LEGATT, Ph.D.
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To the editor: Chronic nausea and anorexia are frequent symptoms in patients with advanced cancer (1, 2). In patients who have no mechanical obstruction of the gastrointestinal tract or who are not receiving potentially emetogenic medication, the cause of these symptoms is generally unknown.
Metoclopramide is an antidopaminergic agent that is useful for the treatment of chemotherapy-induced emesis and of nausea and anorexia associated with diabetes (3). Because of its short half-life (about 4 hours), we thought that a trial of metoclopramide by continuous infusion could eliminate the frequent peaks and troughs associated with oral medication, especially in patients with
BRUERA E, MACDONALD N, BRENNEIS C, et al. Metoclopramide Infusion with a Disposable Portable Pump. Ann Intern Med. 1986;104:896. doi: 10.7326/0003-4819-104-6-896_1
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Published: Ann Intern Med. 1986;104(6):896.
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