GIFFORD S. LEOUNG, M.D.; JOHN MILLS, M.D.; PHILIP C. HOPEWELL, M.D.; WALTER HUGHES, M.D.; CONSTANCE WOFSY, M.D.
All patients with the acquired immunodeficiency syndrome and a first episode of Pneumocystis carinii pneumonia seen at the San Francisco General Hospital between November 1984 and April 1985 were evaluated for oral treatment with dapsone (100 mg/d) plus trimethoprim (20 mg/kg body weight · d). All 15 patients who met the entry criteria improved clinically and radiographically within 3 to 10 days after starting treatment. Repeat pulmonary function tests and gallium lung scans after 3 weeks of therapy also showed improvement. Although side effects occurred in 14 patients, in only 2 were they severe enough to require stopping therapy. Both of these patients had worsening skin rash, and dapsonetrimethoprim therapy was stopped after 10 days. When compared with trimethoprim-sulfamethoxazole or pentamidine used to treat P. carinii pneumonia in similar patients, oral dapsone-trimethoprim is at least as effective, seems to be better tolerated, and may have a lower frequency of serious side effects.
LEOUNG GS, MILLS J, HOPEWELL PC, et al. Dapsone-Trimethoprim for Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1986;105:45–48. doi: https://doi.org/10.7326/0003-4819-105-1-45
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Published: Ann Intern Med. 1986;105(1):45-48.
Infectious Disease, Pulmonary/Critical Care.
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