MARY ALICE HELIKSON, M.D.; ANN D. HAVEY, M.D.; JOSEPH E. ZERWEKH, Ph.D.; NEIL A. BRESLAU, M.D.; DAVID W. GARDNER, M.D.
A teenage boy presented with hypercalcemia and a large intrathoracic mass. Results of an extensive evaluation, including normal findings on parathyroid hormone and urinary 3 , 5-cyclic adenosine monophosphate assays, failed to explain his hypercalcemia. During surgery, a large plasma-cell granuloma of the right middle and lower lobes was resected. Within 2 weeks, serum calcium levels returned to normal. Serum calcitriol (1,25-dihydroxyvitamin D3) levels were elevated before surgery and decreased to normal afterward, correlating with the serum calcium level. Homogenates of the plasma-cell granuloma synthesized a compound indistinguishable from calcitriol.
HELIKSON MA, HAVEY AD, ZERWEKH JE, et al. Plasma-Cell Granuloma Producing Calcitriol and Hypercalcemia. Ann Intern Med. 1986;105:379–381. doi: 10.7326/0003-4819-105-3-379
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Published: Ann Intern Med. 1986;105(3):379-381.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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