MARIA ALOIZOU, M.D.; STEVEN LOMASKY, M.D.; PHILIP D. LIEF, M.D.
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To the editor: In the January issue, Bolan and colleagues (1) describe their analysis of the distribution of pneumococcal serotypes isolated from blood and cerebrospinal fluid of vaccinated and nonvaccinated patients. Although we agree that their data support the use of pneumococcal vaccine in select segments of the population, caution must be used, particularly with regard to meningitis prophylaxis. A reanalysis of the data presented in Table 1 using a fourfold chi-square table reveals a significant increase in the percentage of total cerebrospinal fluid isolates obtained from vaccinated as opposed to nonvaccinated patients: 24. 9% compared with 11.7% (chi-square =
ALOIZOU M, LOMASKY S, LIEF PD. Pneumococcal Vaccine Efficacy. Ann Intern Med. ;105:463–464. doi: 10.7326/0003-4819-105-3-463_2
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Published: Ann Intern Med. 1986;105(3):463-464.
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