YONG-MONG TAN, M.R.C.P. (UK), F.R.A.C.P.; JOHN CROESE, F.R.A.C.P.
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To the editor: Clonidine, an alpha-2-adrenergic receptor agonist, mostly used as an antihypertensive agent, has been reported to be effective in the treatment of diabetic diarrhoea (1). Lower extremity pains in diabetics are often disabling and difficult to treat. Simple analgesics, narcotics, tricyclic antidepressants, clonazepam, carbamazepine, and recently sorbinil, an aldose reductase inhibitor, have all been used (2, 3). We report the cases of three diabetic patients who had excellent symptomatic relief from disabling leg pain after treatment with oral Clonidine.
A 54-year-old man with non-insulin-dependent diabetes was treated with Clonidine, 75 λg twice daily. He reported that it controlled
TAN Y, CROESE J. Clonidine and Diabetic Patients with Leg Pains. Ann Intern Med. ;105:633–634. doi: 10.7326/0003-4819-105-4-633_3
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Published: Ann Intern Med. 1986;105(4):633-634.
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