KODURI R.P. RAO, M.D.
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To the editor: Radiographic contrast media have been reported to cause morphologic "sickling" in vitro of erythrocytes containing hemoglobin S (1). However, complications from angiography in patients with sickle cell disease have been rare (2). The clinical relevance and the significance of the in-vitro observations are unclear (3), but nevertheless, it is recommended that patients with sickle cell anemia be given transfusions before angiography to lower the hemoglobin S level to an arbitrarily set value (4). Whether these recommendations should be applied to patients with hemoglobin S-C disease is not clear.
Before 1983, eight angiographic procedures had been done in
RAO KR. Angiography in Hemoglobin S-C Disease. Ann Intern Med. 1986;105:971. doi: 10.7326/0003-4819-105-6-971_2
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Published: Ann Intern Med. 1986;105(6):971.
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