BRIGGS W. MORRISON, M.D.
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To the editor: Vigano-D'Angelo and associates (1) present interesting hypotheses on protein S in nephrotic syndrome, but I do not believe their data support their conclusions. The authors state, "decreased protein S activity was caused by significant reductions in free (active) protein S levels. . .due to the selective urinary loss of free protein S and elevation of the C4b-binding protein levels. . . that favors complex formation. . ." I would like to examine these conclusions.
First, the authors attempt to demonstrate decreased free protein S levels; they show a statistically significant decrease level of free protein S in
MORRISON BW. Protein S and the Nephrotic Syndrome. Ann Intern Med. 1988;108:152. doi: https://doi.org/10.7326/0003-4819-108-1-152_1
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Published: Ann Intern Med. 1988;108(1):152.
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