LUCINDA G. MILLER, PHARM.D.
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To the editor: I read with interest the article by Radack and associates (1) on the interaction of Ibuprofen and antihypertensive drugs. Although the dosage studied was that normally used via prescription, the article alerts the practitioner to this potential interaction in over-the-counter use as well. The authors' data is in contrast to a similar study where Ibuprofen in a dose of 2400 mg/d produced no hypertensive effects in healthy women (2). Taking these two reports into consideration, it would appear that Ibuprofen affects blood pressure control in hypertensive patients and does not adversely affect normotensive patients.
Whether the adverse
MILLER LG. Ibuprofen and Antihypertensive Drugs. Ann Intern Med. 1988;108:485. doi: 10.7326/0003-4819-108-3-485_1
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Published: Ann Intern Med. 1988;108(3):485.
DOI: 10.7326/0003-4819-108-3-485_1