P.H.J. FRISSEN, M.D.; A. STRONKHORST, M.D.; J.K.M. EEFTINCK SCHATTENKERK, M.D.; S.A. DANNER, M.D.
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To the editor: Pneumocystis carinii pneumonia is the comonest opportunistic infection in the acquired immunodeficiency syndrome (AIDS). Without chemoprophylaxis after initial therapy the relapse rate is up to 80% (1). The use of fansidar (pyrimethamine-sulfadoxine) (Roche Laboratories, Nutley, New Jersey), one tablet a week, is convenient and effective in patients with cotrimoxazole intolerance (2). We report the recurrence of P. carinii pneumonia during chemoprophylaxis with fansidar in two patients.
A 38-year-old homosexual man received a 2-week course of daily high-dose cotrimoxazole (960 mg of trimethoprim and 4800 mg of sulfamethoxazole) for parasitologically proven P. carinii pneumonia with good clinical result.
FRISSEN P, STRONKHORST A, SCHATTENKERK JE, et al. Fansidar and Pneumocystis carinii Pneumonia. Ann Intern Med. 1988;108:638–639. doi: 10.7326/0003-4819-108-4-638_3
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Published: Ann Intern Med. 1988;108(4):638-639.
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