XAVIER MARIETTE, M.D.; BERNARD PAULE, M.D.; PASCAL BENNET, M.D.; DIDIER CLERC, M.D.; MICHEL BISSON, M.D.; PIERRE MASSIAS, M.D.
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To the editor: Hutchinson and associates (1) reported renal salt wasting in 7 of 70 patients treated with cisplatin. These patients had severe persistent orthostatic hypotension requiring prolonged treatment with fludrocortisone and sodium chloride supplements. Six of these patients had hyponatremia (116 to 132 mmol/L). Plasma renin activity and aldosterone concentration were low. The stimulation of vasopressin activity by the resultant hypovolemia might account for the hyponatremia.
Of 20 patients treated with cisplatin during the last 2 years for skeletal metastases, we observed six episodes of transient hyponatremia (less than 130 mmol/L) without symptomatic orthostatic hypotension in 3
MARIETTE X, PAULE B, BENNET P, et al. Cisplatin and Hyponatremia. Ann Intern Med. 1988;108:770–771. doi: 10.7326/0003-4819-108-5-770_2
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Published: Ann Intern Med. 1988;108(5):770-771.
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