KAISS LASSOUED, M.D.; MARIE-NOELLE GUILLY, Ph.D.; FRANÇOISE DANON, M.D.; CHANTAL ANDRE, M.D.; DANIEL DHUMEAUX, M.D.; JEAN-PIERRE CLAUVEL, M.D.; JEAN-CLAUDE BROUET, M.D.; MAXIME SELIGMANN, M.D.; JEAN-CLAUDE COURVALIN, M.D.
In 11 patients, sera displaying a ringlike nuclear immunofluorescent staining on sections of rat liver tissue were shown by Western blotting to contain antibodies to lamins. Sera from 8 patients contained autoantibodies reacting with lamin B, whereas sera from the other 3 patients reacted with lamins A and C. All patients (9 women and 2 men) had a chronic autoimmune disorder, which rarely fulfilled the usual criteria for a diagnosis of systemic lupus erythematosus. The disorder was characterized by acute or chronic (active or granulomatous) hepatitis; steroid-responsive blood cytopenia, often associated with a circulating anticoagulant, or anticardiolipin antibodies, or both; and cutaneous leukocytoclastic angiitis or probable brain vasculitis. Eight patients had at least two of these three conditions. Antilamin autoantibodies may thus be a marker for an unusual subset of autoimmune diseases.
LASSOUED K, GUILLY M, DANON F, ANDRE C, DHUMEAUX D, CLAUVEL J, et al. Antinuclear Autoantibodies Specific for Lamins: Characterization and Clinical Significance. Ann Intern Med. ;108:829–833. doi: 10.7326/0003-4819-108-6-829
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Published: Ann Intern Med. 1988;108(6):829-833.
Gastroenterology/Hepatology, Liver Disease, Lupus Erythematosus, Rheumatology.
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