DANETTA A. BRONNIMANN, M.D.; RODNEY D. ADAM, M.D.; JOHN N. GALGIANI, M.D.; MICHAEL P. HABIB, M.D.; ESKILD A. PETERSEN, M.D.; BRUCE PORTER, M.P.A.; JOHN W. BLOOM, M.D.
Of 27 patients with the acquired immunodeficiency syndrome (AIDS) in Tucson, Arizona, 7 had concurrent coccidioidomycosis. Early manifestations of infection in 6 patients included diffuse nodular pulmonary infiltrates and Coccidioides immitis in many extrathoracic sites. By comparison, a retrospective review of the cases of 300 patients hospitalized with coccidioidal infection identified only 13 patients without AIDS who had the same extent of infection, and only 3 of these patients had no immunosuppressing conditions. Antibodies for coccidioidal antigens at serum dilutions as high as 1:2048 were detected in 5 of the 7 patients with AIDS. Six had temporary responses to amphotericin B treatment, taken both alone and combined with ketoconazole, but all died within 14 months of their diagnosis of coccidioidomycosis. Because annual rates of coccidioidal infection in the Tucson area are 4% or less, the rate of 27% that we calculated, based on 7 patients having the infection during 26 years of risk for AIDS, suggests frequent reactivation of the infection or enhanced susceptibility to endemic exposure in persons with AIDS.
BRONNIMANN DA, ADAM RD, GALGIANI JN, HABIB MP, PETERSEN EA, PORTER B, et al. Coccidioidomycosis in the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;106:372–379. doi: 10.7326/0003-4819-106-3-372
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Published: Ann Intern Med. 1987;106(3):372-379.
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