BASIL J. ZITELLI, M.D.; JEFFREY ALEXANDER, M.D.; SUZANNE TAYLOR, M.D., Ph.D.; KIRK D. MILLER, M.D.; DENISE L. HOWRIE, Pharm.D.; JOEL N. KURITSKY, M.D.; THOMAS H. PEREZ, R.Ph.; DAVID H. VAN THIEL, M.D.
Pyrimethamine-sulfadoxine has been associated with severe and fatal cutaneous reactions as well as transient liver damage. We report the case of a patient who died of progressive hepatic failure caused by pyrimethamine-sulfadoxine administration. In addition, we summarize reports made to the Food and Drug Administration since 1982 that focus on hepatotoxic reactions to pyrimethamine-sulfadoxine. We suggest that fatal hepatic injury can occur after treatment with pyrimethamine-sulfadoxine and that physicians who prescribe the drug should be aware of this possibility.
ZITELLI BJ, ALEXANDER J, TAYLOR S, MILLER KD, HOWRIE DL, KURITSKY JN, et al. Fatal Hepatic Necrosis Due to Pyrimethamine-Sulfadoxine (Fansidar). Ann Intern Med. 1987;106:393–395. doi: 10.7326/0003-4819-106-3-393
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Published: Ann Intern Med. 1987;106(3):393-395.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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