CARROLL E. CROSS, M.D.; BARRY HALLIWELL, D. Sc.; EDWARD T. BORISH, Ph.D.; WILLIAM A. PRYOR, Ph.D.; BRUCE N. AMES, Ph.D.; ROBERT L. SAUL, Ph.D.; JOE M. McCORD, Ph.D.; DENHAM HARMAN, M.D., Ph.D.
Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.
CROSS CE, HALLIWELL B, BORISH ET, et al. Oxygen Radicals and Human Disease. Ann Intern Med. 1987;107:526–545. doi: 10.7326/0003-4819-107-4-526
Download citation file:
Published: Ann Intern Med. 1987;107(4):526-545.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use