RAYMOND J. DATTWYLER, M.D.; JOSEPHINE THOMAS; LAWRENCE C. HURST, M.D.
The cellular immune responses of 12 patients with culture-proved Mycobacterium marinum infection involving deep tissues were studied. Of the 12 patients, 11 failed to respond to M. marinum antigens. All of the patients had, however, normal blastogenic responses to concanavalin A, phytohemagglutinin, pokeweed mitogen, and the antigens tetanus toxoid and Candida albicans. In contrast, 9 of 14 healthy fishermen responded to the M. marinum antigens with significant in-vitro blastogenesis. Infection of deep tissues with M. marinum is associated with antigen-specific T-cell anergy to M. marinum antigens.
DATTWYLER RJ, THOMAS J, HURST LC. Antigen-Specific T-Cell Anergy in Progressive Mycobacterium marinum Infection in Humans. Ann Intern Med. 1987;107:675–677. doi: 10.7326/0003-4819-107-5-675
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Published: Ann Intern Med. 1987;107(5):675-677.
Infectious Disease, Mycobacterial Infections.
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