ADRIAN A. KYRIAKOPOULOS, M.D.
This content is PDF only. Please click on the PDF icon to access.
To the editor: Kremer and colleagues (1) reported "measurable, statistically significant alterations in disease activity" in patients with active rheumatoid arthritis after the administration of fish oil supplements, as compared to placebo. Their statements were based on the results from a crossover trial in which the patients were not randomly assigned to one of the two sequences (fish oil and placebo or placebo and fish oil). Furthermore, the analysis of the data derived from their study showed substantial and unequal carryover effects of the treatments involved during the second "period" of the study.
Under the assumption that all patients were
KYRIAKOPOULOS AA. Rheumatoid Arthritis and Fish Oil. Ann Intern Med. ;107:941. doi: 10.7326/0003-4819-107-6-941_2
Download citation file:
Published: Ann Intern Med. 1987;107(6):941.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use