ADRIAN A. KYRIAKOPOULOS, M.D.
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To the editor: Kremer and colleagues (1) reported "measurable, statistically significant alterations in disease activity" in patients with active rheumatoid arthritis after the administration of fish oil supplements, as compared to placebo. Their statements were based on the results from a crossover trial in which the patients were not randomly assigned to one of the two sequences (fish oil and placebo or placebo and fish oil). Furthermore, the analysis of the data derived from their study showed substantial and unequal carryover effects of the treatments involved during the second "period" of the study.
Under the assumption that all patients were
KYRIAKOPOULOS AA. Rheumatoid Arthritis and Fish Oil. Ann Intern Med. 1987;107:941. doi: https://doi.org/10.7326/0003-4819-107-6-941_2
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Published: Ann Intern Med. 1987;107(6):941.
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