Evlin L. Kinney, MD; Robert J. Wright, BS
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To the Editor: We read with interest the article by Stacpoole and associates (1) on the dichloroacetate treatment in lactic acidosis. The value of their work might be enhanced if there was a way to predict which patients would respond to the treatment. The authors defined a response to dichloroacetate as a decrease of at least 20% in the arterial lactate concentration within 6 hours of the beginning of the first dichloroacetate infusion. If their retreated patients are ignored for the sake of simplicity, 23 patients responded and 6 did not. The authors used conventional statistics to try to distinguish
Kinney EL, Wright RJ. Dichloroacetate and Lactic Acidosis. Ann Intern Med. ;109:435. doi: 10.7326/0003-4819-109-5-435_1
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Published: Ann Intern Med. 1988;109(5):435.
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