Thomas J. Myers, MD; Noubar Kessimian, MD; Stanley Schwartz, MD
The hemophagocytic syndrome is a reactive disorder of the monocyte-macrophage system characterized clinically by an acute onset, fever, lymphadenopathy, hepatosplenomegaly, and pancytopenia (1). The hemophagocytic syndrome can be differentiated from malignant histiocytosis by a potentially self-limited clinical course and by histologic findings of generalized monocyte-macrophage proliferation with prominent hemophagocytosis but without features of malignancy (1, 2). The hemophagocytic syndrome has been reported in association with infections ( 1 ), non-Hodgkin lymphoma (2), Hodgkin disease (3), chronic lymphocytic leukemia (4), acute lymphocytic (5) and nonlymphocytic (6) leukemias, and gastric carcinoma (7).
Extragonadal germ cell tumors are found in 10% to 15%
Myers TJ, Kessimian N, Schwartz S. Mediastinal Germ Cell Tumor Associated with the Hemophagocytic Syndrome. Ann Intern Med. ;109:504–505. doi: 10.7326/0003-4819-109-6-504
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Published: Ann Intern Med. 1988;109(6):504-505.
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