Kwong-Yok Tsang, PhD; Elizabeth A. Johnson, PhD; Mariano F. La Via, MD
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To the Editor: Isoprinosine is a synthetic immunopotentiating agent that can enhance interleukin-2 production in vitro, interleukin-2 receptor expression, natural killer cell activity, mitogen-induced lymphocyte proliferation (1), and macrophage activation (2). It also can produce an anti-cytomegalovirus effect in healthy homosexual men and patients with the acquired immunodeficiency syndrome (AIDS)-related complex, as well as increased total T cells and CD4+ cells and normalization of the CD4+: CD8+ ratio in patients with the AIDS-related complex (3).
A double-blind, placebo-controlled study of isoprinosine was conducted in 16 patients with AIDS-related complex. Patients receiving the drug received 3 g of isoprinosine daily (two
Tsang K, Johnson EA, La Via MF. Anti-p24 Antibody Reactivity in the Acquired Immunodeficiency Syndrome (AIDS)-Related Complex Treated with Isoprinosine. Ann Intern Med. ;109:595. doi: 10.7326/0003-4819-109-7-595_1
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Published: Ann Intern Med. 1988;109(7):595.
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