Mark T. Ruffin IV, MD
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To the Editor: The article on hepatocellular carcinoma (1) provided an excellent update and review of the relevant epidemiology, etiology, diagnosis, and treatment. The discussion of screening and early diagnosis was extremely helpful to those of us caring for refugees from areas of high incidence of hepatocellular carcinoma. However, the authors did not discuss a unique subset of the disease, fibrolamellar hepatocellular carcinoma, which has unique pathologic characteristics and differs from classic hepatocellular carcinoma in several areas.
The histopathologic features of fibrolamellar hepatocellular carcinoma are deeply eosinophilic hepatocytes, many of which contain intracytoplasmic hyaline globules, and distinct pale bodies (2-4).
Ruffin MT. Fibrolamellar Hepatocellular Carcinoma. Ann Intern Med. 1988;109:596–597. doi: https://doi.org/10.7326/0003-4819-109-7-596
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Published: Ann Intern Med. 1988;109(7):596-597.
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