Rosemarie Donhuijsen-Ant, MD; Hinrich Abken, MD; Georg Bornkamm, MD; Konrad Donhuijsen, MD; Hans Grosse-Wilde, MD; Dieter Neumann-Haefelin, MD; Martin Westerhausen, MD; Helga Wiegand, MD
Three brothers from one family died of Hodgkin disease and a fourth brother from a diffuse malignant non-Hodgkin lymphoma. This patient exhibited a constant deficiency of serum immunoglobulins and elevated antibody titers to Epstein-Barr viral antigens. Epstein-Barr virus DNA sequences were detected in DNA isolated from lymph node biopsies from two of the patients. Initially, no abnormalities in the numbers of B and T cells could be detected. Peripheral blood lymphocytes of the patients did not react in the mixed lymphocyte culture assay. We suggest that an immune deficiency to Epstein-Barr virus may favor the proliferation of malignant lymphocytes after Epstein-Barr viral infection. Monoclonal lymphoid B cell lines established spontaneously in vitro from a lymph node biopsy specimen and from peripheral blood specimens from two of the patients. The cells harbor Epstein-Barr viral DNA sequences in multiple genome equivalents and express Epstein-Barr nuclear antigen. The cells contain a tenfold increased level of c-fgr-related RNA transcripts compared with peripheral blood lymphocytes of healthy adults. No obvious amplifications or translocations of the c-myc, c-abl, or c-fgr gene could be detected.
Donhuijsen-Ant R, Abken H, Bornkamm G, et al. Fatal Hodgkin and Non-Hodgkin Lymphoma Associated with Persistent Epstein-Barr Virus in Four Brothers. Ann Intern Med. 1988;109:946–952. doi: 10.7326/0003-4819-109-12-946
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Published: Ann Intern Med. 1988;109(12):946-952.
Hematology/Oncology, Infectious Disease, Leukemia/Lymphoma.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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