Ronald G. Washburn, MD; John E. Bennett, MD
Disseminated histoplasmosis frequently affects the adrenal cortex (1, 2); involvement may range from asymptomatic inflammation of cortical sinusoids with parasitized macrophages (1, 3) to extensive necrosis resulting in potentially fatal Addison disease (1, 2, 4-8). In most reported cases with clinically apparent adrenocortical dysfunction, the assumption was made that tissue destruction was complete and permanent, necessitating lifelong steroid replacement. We report a case of disseminated histoplasmosis in which severely compromised adrenal glucocorticoid function returned to normal after a prolonged course of antifungal chemotherapy with ketoconazole.
A previously healthy 63-year-old black woman noted pruritus over the left vulvar area in January
Washburn RG, Bennett JE. Reversal of Adrenal Glucocorticoid Dysfunction in a Patient with Disseminated Histoplasmosis. Ann Intern Med. ;110:86–87. doi: 10.7326/0003-4819-110-1-86
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Published: Ann Intern Med. 1989;110(1):86-87.
Adrenal Disorders, Endocrine and Metabolism, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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