Janet K. Dale, RN, BSN; Stephen E. Straus, MD; Dharam V. Ablashi, PhD; Zaki S. Salahuddin, PhD; Robert C. Gallo, MD; Yoko Nishibe, PhD; Yukishige K. Inoue, MD
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To the Editor: We are studying the possible role of specific viruses in the chronic fatigue syndrome, an illness for which criteria were recently outlined (1). We summarize the results of a serologic study designed to ascertain whether previous infection with Inoue-Melnick virus is a prominent feature of our patients with the chronic fatigue syndrome and, moreover, whether serologic reactivity to the virus is synonymous with reactivity to herpesviruses, including human herpesvirus type 6 (2).
The Inoue-Melnick virus is not well defined. It resembles the herpesviruses in size, DNA content, sensitivity to organic solvents, and susceptibility to inhibition by drugs
Dale JK, Straus SE, Ablashi DV, Salahuddin ZS, Gallo RC, Nishibe Y, et al. The Inoue-Melnick Virus, Human Herpesvirus Type 6, and the Chronic Fatigue Syndrome. Ann Intern Med. ;110:92–93. doi: 10.7326/0003-4819-110-1-92
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Published: Ann Intern Med. 1989;110(1):92-93.
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