R. Harsha Rao, MD; Anthony H. Vagnucci, MD; Janet A. Amico, MD
Purpose: To develop a clinical perspective on bilateral massive adrenal hemorrhage and an algorithm for its diagnosis and treatment.
Data Identification: Case reports were identified through a computer search using MEDLINE (1976 to 1987), and from bibliographies in review articles (up to 1978).
Study Selection: Twelve reports published since 1978 were found.
Data Extraction: Data from 20 recently reported cases and 5 cases from personal records were compared with data from 142 previously reported, autopsy-proven cases summarized in a 1978 review article.
Results of Data Analysis: Thromboembolic disease, coagulopathy, and the postoperative state were the three major risk factors. Except for abdominal pain and remittent fever, clinical features were not helpful in diagnosis. A fall in hemoglobin, and progressive biochemical hypoadrenalism were important clues. Diagnosis was confirmed by computed tomography and an absent cortisol response to intravenous corticotropin. Long-term follow-up showed complete atrophy and functional failure of the adrenal gland.
Conclusions: Death from bilateral massive adrenal hemorrhage can be prevented by pre-emptive steroid therapy in high-risk patients who have certain clinical and laboratory features.
Rao RH, Vagnucci AH, Amico JA. Bilateral Massive Adrenal Hemorrhage: Early Recognition and Treatment. Ann Intern Med. 1989;110:227–235. doi: https://doi.org/10.7326/0003-4819-110-3-227
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Published: Ann Intern Med. 1989;110(3):227-235.
Adrenal Disorders, Endocrine and Metabolism.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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