Alfonse T. Masi, MD, DrPH
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To the editor: The article by Griffin and colleagues (1) on the use of prescription nonsteroidal anti-inflammatory drugs (NSAIDs) and death from peptic ulcer in elderly enrollees in the Tennessee Medicaid program requires comment. The use of a selective and heterogeneous deceased case group, and of living subjects as the control group raise questions about the validity of the conclusions. Only 122 (25.9%) of 471 persons who died from peptic ulcer or upper gastrointestinal hemorrhage of unknown cause between 1976 and 1984 who met screening criteria were included as "cases" in the study. A significant difference (P < 0.001) by
Masi AT. Nonsteroidal Anti-Inflammatory Drugs and Peptic Ulcer. Ann Intern Med. 1989;110:246–247. doi: https://doi.org/10.7326/0003-4819-110-3-246
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Published: Ann Intern Med. 1989;110(3):246-247.
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