Jerome E. Groopman, MD; David T. Scadden, MD
The observation that recombinant interferon-alpha is an active antineoplastic agent in Kaposi sarcoma associated with the acquired immunodeficiency syndrome (AIDS) grew out of the initial studies of this agent by Krown and colleagues nearly 5 years ago ( 1 ). A clear role for interferon-alpha in therapy for this neoplasm is now emerging.
Kaposi sarcoma is the commonest neoplastic complication of AIDS, occurring in approximately 40% of patients. The marked disparity in the incidence of Kaposi sarcoma in homosexual (approximately 40%) when compared with the incidence in heterosexual (approximately 10%) patients suggests a cause of the sarcoma that is more
Groopman JE, Scadden DT. Interferon Therapy for Kaposi Sarcoma Associated with the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1989;110:335–337. doi: 10.7326/0003-4819-110-5-335
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Published: Ann Intern Med. 1989;110(5):335-337.
Hematology/Oncology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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