Robert Matz, MD
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To the Editor: Although I accept the conclusions of Musher (1), and Lukehart and colleagues (2) concerning the treatment of syphilis in persons positive for human immunodeficiency virus (HIV) infection, I question Dr. Musher's concerns about the currently accepted therapy for primary syphilis in patients without HIV infection.
If our current regimen for the 30% to 40% of patients who have central nervous system invasion with their primary infection is inadequate to sterilize this protected site, what has happened to "classic" parenchymatous neurosyphilis?
I trained in an era when every neurology service in New York had patients with general paresis
Matz R. Therapy for Syphilis. Ann Intern Med. ;110:496. doi: 10.7326/0003-4819-110-6-496_1
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Published: Ann Intern Med. 1989;110(6):496.
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