Stephen S. Gottlieb, MD; Marrick L. Kukin, MD; Madeline Yushak, BA, RN; Norma Medina, RN; Milton Packer, MD
Study Objective: To evaluate the hemodynamic effects of the antiarrhythmic drug, encainide, in patients with severe chronic heart failure.
Design: Unblinded, before-after study.
Setting: Referral center for patients with heart failure.
Patients: Thirty patients with severe chronic heart failure and a left ventricular ejection fraction less than 40%.
Interventions: Invasive hemodynamic measurements were done (using a balloon-tipped thermodilution catheter) before and for 3 hours after a single oral dose of 50 mg of encainide.
Measurements and Main Results: Ninety to one hundred and twenty minutes after its administration, encainide produced a significant deterioration in cardiac performance, as reflected by a fall in cardiac index from 2.3 to 1.8 L/min·m2 body surface
Gottlieb SS, Kukin ML, Yushak M, Medina N, Packer M. Adverse Hemodynamic and Clinical Effects of Encainide in Severe Chronic Heart Failure. Ann Intern Med. ;110:505–509. doi: 10.7326/0003-4819-110-7-505
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Published: Ann Intern Med. 1989;110(7):505-509.
Cardiology, Heart Failure.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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