Douglas K. Pleskow, MD; Harvey J. Berger, MD; John Gyves, MD; Elaine Allen, PhD; Arlene McLean, PhD; Daniel K. Podolsky, MD
Study Objective: To determine the utility of the serologic marker CA19-9 in the diagnosis of pancreatic cancer in patients suspected of having a pancreatic disorder.
Design: Blinded study of frozen pedigreed serum samples collected at time of diagnostic evaluation with follow-up review at a mean of 8 years.
Setting: A general university teaching hospital serving both primary and referral patient populations.
Measurements and Main Results: Sera collected prospectively from 1978 to 1980 from 261 patients undergoing imaging studies of the pancreas (ultrasound, computed tomography, endoscopic retrograde cholangiopancreatography) for a variety of symptoms were assayed for CA19-9 levels, and the results were compared with earlier determinations of other potential markers for pancreatic cancer. In 54 patients ultimately shown to have pancreatic cancer, the CA19-9 assay showed a sensitivity of 70% with a median value of 349 u/mL (normal < 70 u/mL) and range, 7.3 to 2 859 964 u/mL, whereas specificity of the marker in this population was 87%. The positive predictive value was 59%, and the negative predictive value was 92%. Results of CA19-9 testing in the small group of patients with definitive staging information showed no difference in sensitivity between patients with local/regional disease (n = 6) and those with distant metastases (n = 14), 50% compared with 71% (P= 0.613).
Conclusion: CA19-9 was found to be a more sensitive and specific marker of pancreatic cancer than other serologic markers and should be a useful test in the patient with suspected pancreatic disease.
Annals of Internal Medicine. 1989;110:704-709.
Pleskow DK, Berger HJ, Gyves J, et al. Evaluation of a Serologic Marker, CA19-9, in the Diagnosis of Pancreatic Cancer. Ann Intern Med. 1989;110:704–709. doi: https://doi.org/10.7326/0003-4819-110-9-704
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Published: Ann Intern Med. 1989;110(9):704-709.
Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology, Pancreatic Cancer, Pancreatic Disease.
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