Susan S. Braithwaite, MD; Mary Ann Emanuele, MD; Sonia Collins, MA
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To the Editor: In polycystic ovary syndrome (1) and in idiopathic hirsutism (2), the release of delta-5 steroids after administration of adrenocorticotropic hormone (ACTH) closely resembles an exaggeration of the pattern seen in normal adrenarche. In precocious adrenarche the levels of the delta-5 androgens dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) are most clearly abnormal for age (3), and children who are affected have a high incidence of central nervous system dysfunction.
In three adult women with neuropsychiatric disease who presented to us recently with hirsutism, the DHEAS concentrations at times equaled or exceeded 6.0 µg/mL (16.3 µM/L), a level reported by
Braithwaite SS, Emanuele MA, Collins S. Neuropsychiatric Hirsuitism. Ann Intern Med. 1989;110:748–749. doi: https://doi.org/10.7326/0003-4819-110-9-748
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Published: Ann Intern Med. 1989;110(9):748-749.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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