L. Gürtler, MD; J. Eberle; F. Deinhardt
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To the Editor: Seroreversion from positive for anti-bodies to human immunodeficiency virus (HIV) to negative (1) can have far-reaching effects, and the methods and statistics defining such cases should be examined carefully. Western blot tests, enzyme-linked immunoabsorbent assays (ELISA), and radioimmunoprecipitation assay (RIPA) are used to detect the presence of HIV antibodies. The RIPA is the most sensitive, and the reaction patterns reflect this: For example, antibodies detected by Western blot or ELISA, or both, are detected by RIPA, but the converse is not always true. The study by Farzadegan and colleagues (1) (their Table 2) shows such unusual patterns
Gürtler L, Eberle J, Deinhardt F. Seroreversions in Human Immunodeficiency Virus (HIV) Infection. Ann Intern Med. 1989;110:946–948. doi: https://doi.org/10.7326/0003-4819-110-11-946
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Published: Ann Intern Med. 1989;110(11):946-948.
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