Robert C. Collins, MD; Bruce H. Dobkin, MD; Dennis W. Choi, MD, PhD
Stroke is a major cause of morbidity and mortality in the United States with 250 000 cases per year. Cerebral ischemia is the largest category of stroke with cardiac arrest, profound hypotension, and vascular occlusion the principal causes. Traditional approaches to the treatment of ischemic stroke focus on maintaining cardiac output, blood pressure, cerebral blood flow, and on preventing thrombosis. Recently, attention has been focused on developing new therapies that are directed toward abnormal biochemical events at excitatory synapses. Ischemia causes impairment of brain energy metabolism and the release of excessive amounts of glutamate into the extracellular space. This process
Collins RC, Dobkin BH, Choi DW. Selective Vulnerability of the Brain: New Insights into the Pathophysiology of Stroke. Ann Intern Med. 1989;110:992–1000. doi: 10.7326/0003-4819-110-12-992
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Published: Ann Intern Med. 1989;110(12):992-1000.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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