P. S. Sarma, MD
Norfloxacin is a potent antibacterial agent that inhibits the action of topoisomerase II (1, 2). The chance discovery of simultaneous eradication of Plasmodium falciparum and Pseudomonas aeruginosa by norfloxacin prompted the author to report the results of treating uncomplicated falciparum malaria with norfloxacin.
Nine adult patients hospitalized for falciparum malaria were studied. The patient group consisted of seven men and two women; the mean age was 28.1 years. Asexual forms of P. falciparum were seen on peripheral blood smears. The number of parasites per 200 leukocytes was calculated on Leishman-stained thick blood film. Patients who were severely
Sarma PS. Norfloxacin: A New Drug in the Treatment of Falciparum Malaria. Ann Intern Med. ;111:336–337. doi: 10.7326/0003-4819-111-4-336
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Published: Ann Intern Med. 1989;111(4):336-337.
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