Christopher M. Hughes, MD
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To the Editor: Liver function has been increasingly identified as a central factor in the pathogenesis of the sepsis syndrome, the adult respiratory distress syndrome, and the multiple organ failure syndrome (1). Corticosteroids have been tried as both prophylaxis and treatment for these syndromes, more successfully in the former than in the latter situation (2). Treatment in humans has been shown to be relatively contraindicated once the sepsis syndrome has already been identified (2).
These observations generate interest in the findings of Carithers and colleagues (3) as they relate to the mechanism by which mortality was decreased in the group
Hughes CM. Mortality in Alcoholic Hepatitis. Ann Intern Med. ;111:344–345. doi: 10.7326/0003-4819-111-4-344
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Published: Ann Intern Med. 1989;111(4):344-345.
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