Kanji Sato, MD; Minoru Ozawa, MD; Hiroshi Demura, MD; Toru Fujii, MD
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To the Editor: In a recent issue, LoPresti and colleagues (1) reported that serum triiodothyronine (T3) is normal and reverse T3 (rT3) is decreased in emaciated patients with AIDS. This finding is highly unexpected because the T4 levels of such patients are normal or supranormal due to elevated serum thyroxine-binding globulin. Such an inappropriately increased T3/T4 and decreased rT3/T4 ratio contrasts sharply with those usually seen in patients with non-thyroidal illnesses: In these patients, the serum T3 concentration is decreased and rT3 is reciprocally increased (2). This low-T3, high-rT3 state is caused by the adaptation of iodothyronine-5′-deiodinating enzymes for energy-saving
Sato K, Ozawa M, Demura H, et al. Thyroid Function in the Acquired Immunodeficiency Syndrome (AIDS). Ann Intern Med. 1989;111:857–858. doi: https://doi.org/10.7326/0003-4819-111-10-857
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Published: Ann Intern Med. 1989;111(10):857-858.
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