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The advent of magnetic resonance imaging and other advanced imaging techniques has changed neurology immensely. Further, the development of third-generation cephalosporins—the drugs of choice for gram-negative central nervous system infections—has altered prognosis enormously. These advances, coupled with international travel, prolonged cancer therapy, and increased transplant surgery, make parasitic, fungal, and unusual central nervous system infections more commonplace and no longer "zebras." The editors of this third edition have omitted AIDS and viral infections of the central nervous system as they will address these massive materials in a special issue.
Over 42 of the world's outstanding physicians have written a vigorous,
Handbook of Clinical Neurology: Volume 52: Microbial Disease. Ann Intern Med. 1990;112:314. doi: https://doi.org/10.7326/0003-4819-112-4-314_2
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Published: Ann Intern Med. 1990;112(4):314.
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