Maria Grazia Rumi, MD; Massimo Colombo, MD; Alessandro Gringeri, MD; Pier Mannuccio Mannucci, MD
Non-A, non-B hepatitis is common in hemophiliacs infused with clotting factors concentrates (1, 2). Using serum alanine aminotransferase (ALT) as a surrogate test for diagnosis, the proportion of hemophiliacs with chronic infection varies greatly, ranging from 20% (3) to 77% (4). Accurate estimation of chronic infection may be important clinically, because up to 20% of the patients may develop cirrhosis and hepatocellular carcinoma (5, 6). With the advent of a serologic assay for diagnosing infection with the hepatitis C virus (HCV), the major causative agent of blood-borne non-A, non-B hepatitis (7, 8), the real frequency of chronic infection in hemophiliacs
Rumi MG, Colombo M, Gringeri A, Mannucci PM. High Prevalence of Antibody to Hepatitis C Virus in Multitransfused Hemophiliacs with Normal Transaminase Levels. Ann Intern Med. ;112:379–380. doi: 10.7326/0003-4819-112-5-379
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Published: Ann Intern Med. 1990;112(5):379-380.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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