John A. Baron, MD, MS, MSc; Richard D. Folan, MD; Maurice L. Kelley Jr., MD
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To the Editor: The apparent protective effect of cigarette smoking on ulcerative colitis (1) suggests that inhaled plant products might affect the disease process. We report a case suggesting a relation between ulcerative colitis and smoking marijuana.
In 1972, a 23-year-old woman developed abdominal pain, diarrhea, and rectal bleeding. Sigmoidoscopy to 15 cm revealed diffuse cobblestone ulcerations, and a single-contrast barium enema showed numerous small marginal irregularities in the distal sigmoid and rectum. Ulcerative colitis was diagnosed, and her symptoms waxed and waned despite treatment with sulfasalazine, librax, and intermittent prednisone. Discouraged, she stopped all medications in 1975. In 1976,
Baron JA, Folan RD, Kelley ML. Ulcerative Colitis and Marijuana. Ann Intern Med. 1990;112:471. doi: https://doi.org/10.7326/0003-4819-76-3-112-6-471_1
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Published: Ann Intern Med. 1990;112(6):471.
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