Michael D. Murray, PharmD; D. Craig Brater, MD
A number of clinical conditions, including congestive heart failure, cirrhosis, and renal insufficiency, require local synthesis of vasodilating prostaglandins to maintain renal perfusion (for review, see 1-3). When patients with these disorders receive nonsteroidal anti-inflammatory drugs (NSAIDs), they are at risk for an acute ischemic insult to the kidney because inhibition of these prostaglandins allows unopposed vasoconstriction to occur. Numerous interventional (as opposed to epidemiologic) studies have been done that incorporate study designs generally similar to that reported by Whelton and colleagues in this issue (4). The collective results of such studies show that a large proportion of patients preselected
Murray MD, Brater DC. Adverse Effects of Nonsteroidal Anti-inflammatory Drugs on Renal Function. Ann Intern Med. ;112:559–560. doi: 10.7326/0003-4819-112-8-559
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Published: Ann Intern Med. 1990;112(8):559-560.
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