Murthy S. Badiga, MD; Nagarjuna Yerra, MD; Joseph M. Navone, MD
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To the Editor: Disappointingly, the diagnostic criteria for pernicious anemia used in the study by Talley and colleagues (1) were less stringent than those used in other studies. Any patient with anemia characterized by vitamin B12 deficiency due to such diverse causes as improper nutrition, malabsorption syndromes including intestinal disease and resection, bacterial overgrowth, and pancreatitis would have met the requirements and could have been erroneously included in the study as having pernicious anemia.
The authors mentioned that "a portion" of the study period antedated the specific tests currently available for diagnosing pernicious anemia. This being the case, was there
Badiga MS, Yerra N, Navone JM. Pernicious Anemia and Colorectal Cancer. Ann Intern Med. ;112:630–631. doi: 10.7326/0003-4819-112-8-630_2
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Published: Ann Intern Med. 1990;112(8):630-631.
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