Pol Stanislas, MD; Françoise Driss, MD; Agnès Devergie, MD; Christian Brechot, MD, PhD; Pierre Berthelot, MD; Eliane Gluckman, MD
Objective: To determine whether hepatitis C virus is involved in hepatitis-associated aplastic anemia.
Design: Retrospective analysis.
Setting: Bone marrow transplantation unit.
Patients: One hundred and eighteen patients with severe aplastic anemia, including 19 with hepatitis-associated aplasia, 61 with aplastic anemia of undetermined cause, and 38 with aplastic anemia related to an inherited syndrome or an acquired etiology.
Measurements and Main Results: There was no statistically significant difference in antihepatitis C virus antibodies between hepatitis-related aplastic anemia (15.8%; 95% CI, 4% to 36%) and aplasia of unknown (9.8%; CI, 5% to 22%) or known (7.9%; CI, 2% to 22%) cause. The antihepatitis C virus levels did not differ according to the cause of aplastic anemia. There was no relation between hepatitis C and hepatitis B virus serologies, regardless of cause.
Conclusions: Hepatitis C virus is not a frequent cause of non-A, non-B hepatitis-associated aplastic anemia. Either a non-A, non-B, non-C hepatitis virus is involved in non-A, non-B hepatitis-related aplasia or hepatitis C virus prevalence is underestimated in patients with hepatitis-related aplasia, possibly as a result of immunologic defects.
Stanislas P, Driss F, Devergie A, et al. Is Hepatitis C Virus Involved in Hepatitis-Associated Aplastic Anemia?. Ann Intern Med. 1990;113:435–437. doi: https://doi.org/10.7326/0003-4819-113-6-435
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Published: Ann Intern Med. 1990;113(6):435-437.
Gastroenterology/Hepatology, Hematology/Oncology, Infectious Disease, Liver Disease, Red Cell Disorders.
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