Sandy A. Furey, PhD, MD
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To the Editors: Whelton and colleagues (1) have noted an increase in serum creatinine or potassium in 3 of 12 patients with "asymptomatic, mild but stable chronic renal failure" who received Ibuprofen, 800 mg three times a day, and in 2 of those 3 patients receiving Ibuprofen, 400 mg three times a day, for up to 11 days. Concluding that these findings are of particular concern to users of nonprescription Ibuprofen is puzzling: The average glomerular filtration rate for the 3 patients who showed an increase in serum creatinine or potassium was approximately 24.6 mL/min, a far more serious degree
Furey SA. Ibuprofen and Renal Disease. Ann Intern Med. ;113:481. doi: 10.7326/0003-4819-113-6-481
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Published: Ann Intern Med. 1990;113(6):481.
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